Background

The enrichment in bioavailability of the drugs is one of the most important concerning aspects of the pharmaceutical industries. Preparation of nano or micro particles of these drugs is the newest formulation strategies. In general, the drug delivery system needs narrow particle size distribution with regular particle shape, particularly, an engineered drug particles to meet biopharmaceutical and processing needs. The advantages of sonochemistry include four aspects:

• a facile, green and nonhazardous synthesis
• rapid reaction rates
• controllable reaction conditions
• the capability to prepare nano particles with a uniform shape and narrow size- distribution in large scale

A temperature controlled continuous flow-spray sonochemcial system (SCS) is proposed here for prepare herbal extract encapsulated nanocarriers that provides for a tunable particle size and narrow size distribution in the submicron regime. The natural herbal extract is explored as a test case. The diameter of herbal extract encapsulated nanocarriers could be controlled systematically over the range from 100 to 200 nm by varying operation conditions. Also the addition of low concentrations of either a nonionic or anionic surfactant is added to the anti solvent before spray solvent through sonohorn. The structural, morphology, composition and colloidal stability of as-prepared nano-herbsuls were studied by XRD, FTIR, SEM, UV-Vis-NIR and Zeta- DLS techniques.

Integrated continuous flow reactor vessel – solvent spray sonohorn based new sono chemical systems for rapid, one-pot, green synthesis of nano encapsulation of herbal extracts for therapeutic applications is developed as a laboratory prototype and its testing is in progress. New nanoherabl extracts encapsulated carriers for therapeutic applications will be developed.